Pion Inc. Is on the Verge of Releasing Brand New FLUX Technology
Billerica, MA, USA—July 12, 2016—Pion is on the verge of releasing brand new FLUX technology. Building on the success and effectiveness of the µFLUX, Pion continues to invest in and develop within the FLUX product line.
Introducing the MacroFLUX
The need to test finished drug products for their absorption potential in order to predict pharmacokinetic performance has been a topic of great interest to the drug development community. In many cases, dissolution experiments alone cannot correctly predict the in vivo response to drug products due to the complicated interplay of solubility and permeability in complex media. Pion’s MacroFLUX device extends the utility of in situ concentration monitoring to improved assessment of absorption potential and more realistic IVIVC modeling.
Introducing a stirred absorption chamber into the traditional USP I and II apparatus allows this type of testing to be done in vitro through the use of the MacroFLUX dissolution system. The USP vessel is the donor compartment, allowing for the volumes needed to test finished dosage forms under sink conditions. Using in situ fiber optic UV detection in both the donor and receiver provides the required data density for accurate assessment of transmembrane FLUX. The Pion MacroFLUX will be officially launched at AAPS 2016, with systems available for delivery by the end of the year.
Disposable µFLUX Pairs
In an effort to support and enable the current µFLUX customer base, Pion has developed and released disposable plastic cell pairs. This move to a consumable-based product offering allows users to quickly set up and run µFLUX assays with less downtime and higher throughput. This consumable line is available for immediate purchase. Pion’s µFLUX is a convenient and powerful in vitro tool. Combining the data from a dissolution experiment with trans-membrane permeation, the µFLUX system is the perfect tool for predicting early pharmacokinetic behavior of formulations. Users can assess the effect different formulation vehicles have on FLUX or assess preclinical performance based on pH or food effect.
Conduct small-volume dissolution experiments while at the same time evaluating the absorption potential of a compound—the donor-receiver cell-pair configuration with two compartments separated by a membrane makes this easy! The Rainbow fiber optic monitoring system allows patented real-time display of dissolution and FLUX with the added benefits of temperature control, programmable stirring speed, and simultaneous concentration monitoring of donor and receiver chambers.
The µFLUX device is an add-on option to the µDISS Profiler instrument, consisting of four pairs of temperature-controlled, side-by-side diffusion chambers mounted on top of a stirring platform. Each pair consists of a donor compartment and a receiver compartment separated by a filter-supported, GIT-optimized artificial membrane (Double-Sink PAMPA 2).
About Pion Inc.
Pion Inc. develops and manufactures instrumentation for compound testing in pharmaceutical R&D. These include high-precision fiber optic-based analytical instruments for solubility and dissolution measurements, as well as complete systems for permeability (PAMPA), solubility, and ionization. Additionally, Pion provides CRO services for solubility, permeability, dissolution, pKa, and lipophilicity testing. More information is available at www.pion-inc.com .
Barb Schwartz / Content and Marketing Manager