August 2009 Volume 16 Issue 3

Special Edition on Biorelevant Dissolution: Methodology and Applications

Biorelevant Dissolution: Methodology and Application in Drug Development Qingxi Wang1, Nikoletta Fotaki2, and Yun Mao3 1Analytical Development and Commercialization, Merck and Co, Inc., West Point, PA USA 2Department of Pharmacy and Pharmacology, University of Bath, Bath, UK 3Pharmaceutical R&D, Merck and Co, Inc., West Point, PA USA Evaluation of Dissolution Media Containing a Novel Synthetic Surfactant by In Vitro Testing of BCS Class II Drugs Hitesh Jogia1,2, Tushar Mehta2, and Madhabhai Patel1 1Kalol Institute of Pharmacy, Gujarat, India 2Analytical Development Laboratory, Torrent Pharmaceutical Ltd., Gujarat, India Biorelevant Dissolution Media Simulating the Proximal Human Gastrointestinal Tract: An Update Ekarat Jantratid and Jennifer Dressman Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany Predicting Food Effects on Drug Release from Extended-Release Oral Dosage Forms Containing a Narrow Therapeutic Index Drug Sandra Klein Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany Instant FaSSIF and FeSSIF—Biorelevance Meets Practicality Julia Elisabeth Boni1,2, Rolf Stefan Brickl1, Jennifer Dressman2, and Martin L. Pfefferle1 1Pharmaceutical Research & Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany 2Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany Physicochemical Characterization of Simulated Intestinal Fed-State Fluids Containing Lyso-Phosphatidylcholine and Cholesterol D. G. Fatouros1, I. Walrand1, B. Bergenstah2, and A. Mullertz3 1Department of Pharmaceutics and Analytical Chemistry Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark 2Department of Food Technology, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden 3Bioneer:FARMA, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark Meeting Report: APQ/IPA Workshop on Challenges for Dissolution Testing in the 21st Century Kailas Thakker1 and Vivian Gray2 1President, Analytical Solutions, Inc., Durham, NC. 2Research Editor, Dissolution Technologies, Hockessin, DE Question & Answer Section Margareth Marques and William Brown United States Pharmacopeia, Rockville,MD